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KMID : 0602620010070020213
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Korean Journal of Hepatology
2001 Volume.7 No. 2 p.213 ~ p.215
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A Case of Theophylline-Induced Hepatitis
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임대욱/Dae Wook Rhim
백순구/박용순/박학천/서정인/김현수/리원연/용석중/신계철/이동기/권상옥/김태헌*/조미연*/Soon Koo Baik/Yong Soon Park/Hark Cheon Park/Jeong Ihn Seo/Hyun Soo Kim/Won Yeon Lee/Suk Joong Yong/Kye Chul Sin/Dong Ki Lee/Sang Ok Kwon/Tae Heon Kim*/Mee Yon Cho*
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Abstract
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Theophylline has been widely used in the treatment of asthma and chronic obstructive lung disease. To date, there have been very few reports on hepatotoxicity due to theophylline. We diagnosed, through biochemical testing and a liver biopsy, a
case
of
acute cholestatic hepatitis developed after oral consumption of theophylline. A 43 year-old man was admitted to the department of internal medicine due to jaundice and pruritus which developed after ten days administration of oral theophylline
(Etheophyl ). Liver function tests showed elevated serum bilirubin at 13.2 mg/dL with AST and ALT of 71 U/L and 194 U/L. Alkaline phosphatase and γ-GTP were also elevated at 175 U/L and 301 U/L. There was no evidence of viral or autoimmune
hepatitis in
laboratory tests. The patient's symptoms and liver function tests were improved after conservative treatment. After 9 months oral theophylline was readministered for the control of relapsed asthma. Then, jaundice and pruritus again developed
again.
A
liver biopsy showed a few lymphocytes and eosinophilic inflammatory cell infiltration in portal tract and cholestasis in the lobule. Drug-induced hepatitis was diagnosed with a typical clinical course; the exclusion of all possible causes of
acute
hepatic dysfunction; and a positive response to accidental readministration of drug. We report this case with a review of the literature.
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